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Brain Circuits

Stressed by ambiguity? How to turn problems into opportunities  

Published December 2, 2025 in Brain Circuits • 3 min read

At the core of today’s frequent disruptions is ambiguity: situations where the available information is incomplete, contradictory, or constantly shifting, and clear answers are impossible. In the first of a two-part series, Amy Bonsall and Alyson Meister show how to turn problems into opportunities through reframing your response to perceived threats.

Biological reality

Humans naturally seek to reduce ambiguity. In ambiguous situations, the body’s first response typically isn’t creativity or problem-solving: it’s survival. When we encounter something new or uncertain, our nervous system activates the stress response, often described as “fight, flight, or freeze.” That’s why, in moments of disruption – like a reorganization or sudden shift in market conditions – leaders can find themselves feeling defensive, anxious, or paralyzed rather than open and innovative.

Corporate culture can also keep us in that state. Shareholders don’t want to hear that we don’t know what’s next. Employees want answers. They – and the market – demand confidence and certainty; even when conditions are murky.

 

A new skillset

Unlike machines, we have a biological response to change. And that response, if understood and harnessed, can become a powerful advantage. Navigating ambiguity thus requires a new skillset; one that leans into our humanness rather than bypasses it.

Research shows that, with practice, you can shift from a “threat state,” where stress feels overwhelming, to a “challenge state,” where the same physiological arousal becomes energizing and motivating. Use these strategies to help make the shift:

  • Develop a “stress mindset”
    This means focusing on the enhancing side of stress.
  • Use cognitive reappraisal
    This consists of reframing the experience toward what’s good.
  • Use deliberate pauses
    This gives the cortex (the brain’s decision-making and idea-generating center) time to re-engage.

 

Where to begin

First, thwart the initial threat reaction by creating space to respond instead of reacting. This can involve simply taking a moment to breathe, which can calm a threat response, creating time and space to rethink the challenge ahead. Ask yourself these questions to view an area of uncertainty differently:

  • What has this uncertainty created more space for?
  • What are the unmet customer or employee needs we might now be able to address?

 

Key learning

It’s human nature, when faced with disruption, for leaders to react defensively – but this initial biological response to change can be conquered and harnessed and made into a powerful advantage.

Authors

Amy Bonsall

Leadership coach and founder of Collective

Amy Bonsall is a business-designer, leadership coach, innovation strategist, and founder of Collective, a leadership advisory and capability-building business. Bonsall has a diverse background, having worked at IDEO, where she led the Venture Design practice. She holds an MBA from IMD.

Alyson Meister - IMD Professor

Alyson Meister

Professor of Leadership and Organizational Behavior at IMD

Alyson Meister is Professor of Leadership and Organizational Behavior and Director of the Future Leaders program and the Resilient Leadership Sprint, she is also co-director of the Change Management Program at IMD Business School. Specializing in the development of globally oriented, adaptive, and inclusive organizations, she has worked with executives, teams, and organizations from professional services to industrial goods and technology. She also serves as co-chair of One Mind at Work’s Scientific Advisory Committee, with a focus on advancing mental health in the workplace. Follow her on Twitter: @alymeister.

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